Prothena Corporation plc is classed by the SEC under Pharmaceutical Preparations (industry code 2834), based in Dublin 2, IE. In its latest annual figures on file, for the fiscal year ended 2025-12-31, it reported revenue of $10 million and a loss of $244 million (its filed statements).
Pre-revenue companyPharmaceutical PreparationsDublin 2, IEfilings since 20128 of 9 filed, 1 estimated
Three tenses, nine metrics. Unseen metrics stay unseen; the grade never fakes a number. Proxy era: provisional values, marked. Weighed as a pre-revenue company: no meaningful revenue on file yet (industry code 2834), so it is read as a pre-revenue company; the filing read can change it. All three tenses have at least two readings, so the archetype blend applies as printed.
The grade, in three tenses
Headline 4.9 out of ten, 8 of 9 metrics filed and 1 estimated: past 6.3 out of ten, present 5.8 out of ten, future 3.2 out of ten. The past asks what it actually did, the present what it is doing right now, the future what it is set up to do next.
The nine metrics
Surviving crises (past): 8.2 out of ten. No warning events in its filings since 2017. 82nd percentile among 497 sector filers. A production reading, recomputed from the filings on every data build (read from EDGAR 2026-10-12).
Track record (past): 5.3 out of ten. +39.2% a year over 8 filed years; profitable in 1 of 8. 53rd percentile among 324 sector filers. A production reading, recomputed from the filings on every data build (read from EDGAR 2026-10-12).
Shareholder treatment (past): 6.2 out of ten. CrossAssetData estimate 6.2/10, confidence 35 of 100 (one part). 62nd percentile among 463 sector filers. A CrossAssetData estimate, not a filed reading: one part, confidence 35 of 100; a filing that carries the missing parts replaces this estimate with the filed reading.
Financial health (present): 6.7 out of ten. ROE -87%: lost 87¢ per shareholder dollar. Leverage 14%: owes 14¢ per asset dollar. 67th percentile among 472 sector filers. A production reading, recomputed from the filings on every data build (read from EDGAR 2026-10-12).
Industry position (present): 2.5 out of ten. bottom 25% of 314 in its family; net margin -2520.6%. 25th percentile among 314 sector filers. A production reading, recomputed from the filings on every data build (read from EDGAR 2026-10-12).
Leadership (present): 6.9 out of ten. top 31% of 315 in its family for leadership; chief executive since 2016. 69th percentile among 315 sector filers. A production reading, recomputed from the filings on every data build (read from EDGAR 2026-10-09).
Room to expand (future): 6.5 out of ten. top 35% of 272 in its family for room to expand. 65th percentile among 272 sector filers. A production reading, recomputed from the filings on every data build (read from EDGAR 2026-10-12).
Growth drivers (future): 1.9 out of ten. bottom 19% of 307 in its family for growth drivers. 19th percentile among 307 sector filers. A production reading, recomputed from the filings on every data build (read from EDGAR 2026-10-12).
Expectations vs reality (future): 1.0 out of ten. bottom 10% of 234 in its family for expectations against reality. 10th percentile among 234 sector filers. A production reading, recomputed from the filings on every data build (read from EDGAR 2026-10-12).
The filing record
Newest annual report: Form 10-K filed 2026-02-27 for the period ended 2025-12-31 (on EDGAR). Newest quarterly report: Form 10-Q filed 2026-08-06 for the period ended 2026-06-30 (on EDGAR). Newest results release: Form 8-K filed 2026-08-06 (on EDGAR). Newest filing: Form 4, 2026-10-09. Filings on record since 2012. Read from EDGAR 2026-10-12.
Where the revenue comes from
Product and service lines in fiscal 2025: Collaboration 100%, License 1%. As tagged in its annual report (Form 10-K, filed 2026-02-27).
Who runs it
Kinney, Gene G. (President and CEO); Nguyen, Tran (Chief Strategy Officer and CFO); Smith, Brandon S. (Chief Operating Officer); Kingston, Anne Evans (Chief Strategy Officer); Swanson, Chad J. (Chief Development Officer); Walker, Karin L (Chief Accounting Officer); Zago, Wagner M. (Chief Scientific Officer); Malecek, Michael J (Chief Legal Officer); Isaacs, Michael John (General Counsel & Company Sec.); Collier, Richard T (director); and 5 more. 15 officers and directors have filed their own trades in the last fifteen months, names and titles as filed with the SEC, through 2026-10-09.
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